ATCC9245

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ATCC9245标准菌株基本信息

出品公司: ATCC
菌种名称: ATCC9245, ATCC 9245
菌种又名: 296 [CBS 167.53, DSM 1908, DSM 835, IMI 314507, NRRL 2310]
菌株类型: 雅致小克银汉霉;绮丽小克银汉霉;小克银汉霉菌Cunninghamella elegans
存储人: VM Cutter
分离来源: 亚麻籽,加拿大马尼托巴州温克勒市亚麻籽
产品目录号: 9245
其他保藏库编号: BCRC31841,ATCC 9245 ;CBS 167.53 ;DSM 1908 ;DSM 835 ;NRRL 2310;IMI 314507;VKM F-995
培养基:
ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 323: Malt agar medium
ATCC® Medium 336: Potato dextrose agar (PDA)
生长条件: 24-26℃,  有氧
生物安全等级: 1
模式菌株:
应用: 科研,生产,主要用于水解sclareol,生产9,10-二甲基-1,2-苯并蒽7,12-二甲基苯并[a]蒽,产生肌钙蛋白,生产卡霉素衍生物马格霉素衍生物,产生亮霉素衍生物,生产尼达霉素衍生物,产生类固醇
,转化阿莫沙平,转换阿扎他定,转化溴苯那敏,转化扑尔敏,转化氯丙嗪,转化甲基二嗪,转换苯那敏,转化茄碱,阿莫沙平转化为7-羟基阿莫沙平,倍半萜内酯-科斯图内酯的转化,藤架改为藤架亚砜
菌株特点:
ATCC 9245是雅致小克银汉霉,Cunninghamella elegans 。Nucleotide (GenBank) : M36310 Cunninghamella elegans 5S ribosomal RNA.
 
参考文献:
 
Bloom BM, Shull GM. Epoxidation of unsaturated steroids by microorganisms. J. Am. Chem. Soc. 87: 5767-5768, 1965.
 
Wong LK, et al. Metabolism of 7,12-dimethylbenz[a]anthracene by Cunninghamella elegans. Appl. Environ. Microbiol. 46: 1239-1242, 1983. PubMed: 6418073
 
Theriault RJ. Mycarosyl macrolide antibiotics. US Patent 3,784,447 dated Jan 8 1974
 
Wolf-Rainer A. Microbial hydroxylation of sclareol. Phytochemistry 36: 1421-1424, 1994.
 
Zhang D, et al. Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans. Appl. Environ. Microbiol. 62: 798-803, 1996. PubMed: 8975609
 
Hansen EB Jr., et al. Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N- demethylated metabolites by the fungus Cunninghamella elegans. Xenobiotica 25: 1081-1092, 1995. PubMed: 8578764
 
Zhang D, et al. Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. Appl. Environ. Microbiol. 62: 3477-3479, 1996. PubMed: 8795241
 
Moody JD, et al. Transformation of amoxapine by Cunninghamella elegans. Appl. Environ. Microbiol. 66: 3646-3649, 2000. PubMed: 10919836
 
Betts RE, et al. Microbial transformations of antitumor compounds. I. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata. J. Med. Chem. 17: 599-602, 1974. PubMed: 4829940
 
Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979.
 
Smith RV, et al. Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone. J. Pharm. Sci. 72: 733-736, 1983. PubMed: 6684155
 
Patel AV. Transformations of solasodine and derivatives of hecogenin by Cunninghamella elegans. Phytochemistry 35: 125-133, 1994.
 
Walther G, et al. DNA barcoding in Mucorales: an inventory of biodiversity. Persoonia 30: 11-47, 2013. PubMed: 24027345
 
Vitale RG, et al. Antifungal susceptibility and phylogeny of opportunistic members of the order Mucorales. J Clin Microbiol 50: 66-75, 2012. PubMed: 22075600

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